Welcome to Ken Weiss' Lab on the web
Recent Papers
Here are some recent papers that may be of interest.
Note: the papers with titles in bold are available in pdf format. I can't post the files, but as you would in a library, you can have a copy for your personal use. Please email me at kenweiss@psu.edu to request a pdf and I'll send it to you.
Weiss, KM Is there a 'paradigm' shift in genetics? Lessons from the study of human diseases Molecular Phylogenetics and Evolution, 5:259-265, 1996.
Weiss, K, Zhao, Z, Stock, D Dynamic interactions and dental patterning. Cr Rev Oral Biol and Med, 9:369-398, 1998
Nickerson, D, Taylor S, Weiss, K, Clark, A, Hutchinson, R, Stengard, J, Salomaa, V, Vartianinen, E, Boerwinkle, E, Sing, C DNA sequence diversity in a 9.7kb region of the human lipoprotein lipase gene. Nature Genetics, 19:233-240, 1998.
Clark, A, Weiss, K, Nickerson, D, Taylor, S, Buchanan, A, Stengard, J, Salomaa, V, Vartianinen, E, Boerwinkle, E, Sing, C Haplotype structure and population genetic inferences from nucleotide sequence variation in human lipoprotein lipase. Am J Human Genet, 63:595-612, 1998.
Weiss, KM In search of human variation. Genome Res., 8:691-697, 1998
Weiss, KM Coming to terms with human variation. Ann Rev Anthropol, 27: 273-300, 1998.
Terwilliger, J, Weiss, K. Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Op Biotechnol, 9:578-594, 1998.
Weiss, K, Fullerton, SM Phenogenetic Drift and the evolution of genotype-phenotype relationships Theor. Pop. Biol, 57: 187-195, 2000.
Weiss, K, Buchanan, A Rediscovering Darwin after a Darwinian Century, Evol Anthropol., 9: 187-200, 2000.
Weiss, K, Terwilliger, J How many diseases do you hav to study to map one gene with SNPS? Nature Genetics, 26: 151-157.
Weiss, K.M. Consulting the oracle: reverece, but circumspection Analytic book review of McKusick V, et al. Eds, Mendelian Inheritance in Man, 12th ed, Genetic Epidemiol 19: 468-472, 2001.
Weiss, KM *Omics: A Quick Guide. Physical Anthropol (Newsletter item), 1(4):3-4, 2001.
Buchanan, A, Risch, G, Robichaux, M, Sherry, S, Batzer, M, Weiss, K. Long DOP-PCR of rare archival anthropological samples. Human Biology 72: 911-926, 2001.
Fullerton SM, Clark AG, Weiss KM, Nickerson DA, Taylor SL, Stengard JH, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing CF. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism Am J Hum Genet. 67:881-900, 2001.
Zhao, Z, Stock, D, Buchanan, A, Weiss, K. Expression of Dlx genes during murine dental development,Dev, Genes, Evol., 210: 270-275, 2001.
Weiss, K. Revisiting phenotypes in an age of genotypes. Am J Phys Anthropol, 111: 295-299, 2001.
Weiss, K, Clark, A Linkage disequilibrium and the mapping of complex human traits. Trends in Genetics, 18:19-24, 2002.
Sumiyama, K, Irvine, S, Stock, D, Weiss, K, Kawasaki, K, Shimizu, N, Shashikant, C, Miller, W, Ruddle, F. Genomic structure and functional control of the Dlx3-7 bigene cluster Proc Nat Acad Sci 99: 780-785, 2002.
Hlusko, L, Mahaney, M, Rogers, J, Weiss, K. A Comparison of Two Techniques to Describe Molar Crown Size: Estimated Crown Area versus Actual Crown Area. Am J Phys Anth, 117: 172-189, 2002.
Weiss, K, Schull, W Perspectives fulfilled: the work and thought of JV Neel (1915-2000) Persp. Biol.Med, 45:46-64, 2002.
Kawasaki, K, Weiss, KM Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster Proc Nat Acad Sci 100:4060-4065, 2003.
Weiss, K., Buchanan, A. Evolution by phenotype: a biomedical perspective. Pers. Biol. Med. 46: 159-182, 2003.
Weiss, K. Richard H Ward: W ild Ride of the Valkyries (obituary). Am. J. Hum. Genet. 72:1079-1083, 2003.
Stengard, J. et al. Contributions of 18 additional DNA sequence variations in the gene encoding for apolipoprotein E to explaining variation in quantitative measures of lipid metabolism Am J Hum Genet, 71: 501-517, 2003.
Fullerton, SM et al. Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in African-American sample Hum. Genet. 111: 75-87, 2004.
Terwilliger, JG, Weiss, KM Confounding, ascertainment bias, and the quest for a genetic "Fountain of Youth". Annals of Medicine, 35:532-544, 2003.
Kittles, R, Weiss, KM Race, ancestry, and genes: implications for defining disease risk. Annual Rev Human Genomics and Human Genetics, 4: 33-67, 2003.
Weiss, K. Thomas Henry Huxley (1825-1895) puts us in our place. M Exper Zool/Mol Dev Evol, 302B: 196-206, 2004.
Weiss, K. The unkindest cup. The Lancet, 363: 1489-1490, 2004.
Kawasaki, K, Suzuki, T, Weiss, K. Genetic basis for the evolution of vertebrate mineralized tissue, Proc. Natl. Acad. Sci., 101:11356-61, 2004.
Fullerton, SM et al. The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Hum. Genet. 115: 36-56, 2004.
Sholtis, S, Weiss, K. Phenogenetics: Genotype-phenotype interactions and variation. In B Hallgrimsson and BK Hall, eds., Variation, NY: Academic Press.
Weiss, K. The phenogenetic logic of life. Nat. Rvws Genet. 6: 36-45, 2005.
Weiss, K. Cryptic causation of human disease: reading between the (germ) lines. Trends in Genetics, 21(2): 82-88.
Weiss, K. Polymorphisms: origin and maintenance. Encyclopedia of the Life Sciences
Weiss, K., Buchanan, A. Concept of complex trait genetics.
Cambridge Encyclopedia of Genetics,
Genomics, Proteomics And Bioinformatics, Ch 58.
Weiss, K. 'Genetic': one word, several meanings.
Invited chapter for Scriver, C. et al., eds,
The Metabolic and Molecular Basis of Inherited Disease, Chapter 2.1.
Weiss, K. Allele spectrum in human genetic disease, Encyclopedia of the Life Sciences.
Buchanan, A, Weiss, K , Fullerton, SM Dissecting complex
disease: the quest for the philosopher’s
stone? (a forum article with commentary and our reply), International
J. Epidemiol. 35: 562-596, 2006.
Kawasaki, K, Weiss, K Phenogenetic drift in vertebrate tooth evolution: the changing genetic basis of vertebrate teeth, PNAS, 102: 18063-68, 2005.
Kawasaki , K, Weiss, K. Evolutionary genetics of vertebrate
tissue mineralization: the origin
and evolution of the secretory calcium-binding phosphoprotein family.
Mol. Dev. Evol./J Exper Zool. 306:295-316, 2006.
Kwasaki, K, Weiss, K , Genetic Basis for the Evolution of Vertebrate Mineralized Tissue. In, Baeuerlein, E, Ed., Handbook Of Biomineralization, Vol. 1: The Biology of Biominerals Structure Formation, Chapter 21, Berlin, Wilyey-VCH, 2006.
Weiss, K., Smith, FH Out of the veil of death rode the one
million! Neandertals and their genes.
BioEssays, invited commentary, 29(2):105-110, 2007.
Kawasaki, K,Buchanan, A., Weiss, K Gene Duplication and the
Evolution of Vertebrate Skeletal
Mineralization, Cells, Tissues, and Organs, 186, No. 1,
7 – 24, 2007
Weiss, K. On babies and bathwater (Commentary). Amer. Ethnol., 34:240-242.
Mao, X, Bigham, A, Mei, R., Gutierrez, G, Weiss, K, Brutsaert, T, Leon-Velarde, F, Moore, L.,
McKeigue, P., Shriver, M., Parra, E. A genome-wide admixture mapping panel for Hispanic/Latino
populations. Am. J. Hum. Genet., 80:1171-1178.
Weiss, K. Overview thoughts on genetics: Walking the line between denial and dreamland, or genes are
involved in everything but not everything is ‘genetic’. Chapter 12 in Weinstein, M, Vaupel, J, Wachter,
K, Eds. Biosocial Surveys. Washington, National Academies Press, pp 231-247.
Kawasaki, K, Weiss, K SCPP genes and the dental tissue continuum. J Dent Res., in press
Weiss, K., Buchanan, A The cooperative genome. Int J Developmental Biol., in press.
BOOKS:
Weiss, K, Buchanan, A. The Mermaid’s Tale. Accepted, in revision, Harvard Univ Press, due Fall ‘08
Weiss, KM, Buchanan, AV Genetics and the Logic of Evolution.
NY, J. Wiley, 2004.
